ABSTRACT
Objectives To evaluate the PSA in a large population of Brazilian men undergone to check up, and correlate the PSA cutoffs with prostate size and urinary symptoms. Materials and Methods This is a cross sectional study performed with men between 40 and 70 years undergone to check-up. All men were undergone to urological evaluation, digital rectal examination, prostate-specific antigen, and ultrasonography The exclusion criteria were men who used testosterone in the last six months, or who were using 5 alpha-reductase inhibitors. Results A total of 5015 men with an average age of 49.0 years completed the study. Most men were white and asymptomatic. The PSA in the three different aging groups were 0.9 ± 0.7ng/dL for men between 40 and 50; 1.2 ± 0.5ng/dL for men between 50 and 60; and 1.7 ± 1.5ng/dL for men greater than 60 years (p=0.001). A total of 192 men had PSA between 2.5 and 4ng/ml. From these men 130 were undergone to prostate biopsy. The predictive positive value of biopsy was 25% (32/130). In the same way, 100 patients had PSA >4ng/mL. From these men, 80 were undergone to prostate biopsy. In this group, the predictive positive value of biopsy was 40% (32/100). The Gleason score was 6 in 19 men (60%), 7 in 10 men (31%) and 8 in 3 men (9%). Conclusions The PSA level of Brazilian men undergone to check up was low. There was a positive correlation with aging, IPSS and prostate size. .
Subject(s)
Adult , Aged , Humans , Male , Middle Aged , Early Detection of Cancer/methods , Prostate-Specific Antigen/blood , Prostate/pathology , Prostatic Neoplasms/pathology , Age Factors , Analysis of Variance , Biopsy , Brazil , Cross-Sectional Studies , Digital Rectal Examination , Organ Size , Predictive Value of Tests , Prostate , Prostatic Neoplasms/bloodABSTRACT
Com a introduçao dos inibidores da enzima conversora da angiotensina (IECAs) - peptídios que inibem a atividade da cinase e têm potente açao inibitória sobre a conversao da angiotensina I em angiotensina II -, o tratamento da ICC e da HA evoluiu consideravelmente. A eficácia clínica destas drogas estimulou o interesse internacional em pesquisar o sistema renina-angiotensina, possibilitando assim a descoberta do sistema renina-angiotensina tecidual, a presença de receptores específicos para angiotensina II neste sistema e de antagonistas nao-peptídicos seletivos para estes receptores.